Blog Archives

Developmental inflammation

2/28/2023

Val's Take
We're starting to see Mental Health Outpatient Treatment at Schools and more recognition of the need for a CONTINUUM OF CARE from SECURE PLACEMENTS to PUBLIC EDUCATION --

When it comes to the many health consequences of HIGH LEVELS of DEVELOPMENTAL INFLAMMATION

Metabolic Dysregulation
- People are having to work a lot HARDER than they have in the past to maintain a healthy weight.
  - that is a TIME COST and a FINANCIAL COST.
  - in some cases, there is a need for very sophisticated medical intervention

Endocrine Dysregulation
- Ramped Up Stress Responses that require conscious effort to manage ---
  - that is a TIME COST and a FINANCIAL COST.
  - in some cases, there is a need for very sophisticated medical intervention.

Dysregulation of the Microbiome
- literally TRILLIONS OF FACTORS
- improved diet will likely help
  - this can be a TIME COST and a FINANCIAL COST
- some cases, there may be the need for sophisticated medical intervention

Dysregulation of the Immune System

Autoimmune Problems
Many more functions than previously appreciated ---
- Recently recognized --- Social Interactions are a DELICATE BALANCE of the INNATE & ADAPTIVE IMMUNE SYSTEMS.
Recently recognized --- the immune system has DIRECT PIPELINES TO THE BRAIN.

Dysregulation of the Central Nervous System

Dysregulation of the Cardio-Vascular System

All of these systems are INTER-RELATED and their Functioning is INTEGRATED.

Our Understandings Need to be INTEGRATED, TOO.

The DYSREGULATIONS are highly IDIOSYNCRATIC and are DRIVING the need for PRECISION MEDICINE and INDIVIDUAL TAILORING of LIFESTYLES.

Inflammation & the Developing Brain

New insights into the detection, pathophysiology and treatment of inflammation-induced injury in the immature brain

The immature brain is especially vulnerable to inflammatory factors, before, during and after birth. This publication presents new insights into the detection, pathophysiology and treatment of inflammation-induced injury in the developing brain from both clinical and basic science perspectives.

Cellular mechanisms that lead to perinatal brain injury are presented, with specific emphasis on inflammation, brain development and potential treatment strategies. In particular, studies report on inflammatory pathways involved in perinatal brain injury, including caspases, STAT3, toll-like receptors and oxidative stress. Some data demonstrate how different inflammatory cell types may contribute to the injury, such as microglia and mast cells, and how peripheral organs can influence the cerebral inflammatory response.

Further, new developments in neuroprotective therapies using human amnion epithelial cells to reduce inflammation-induced brain damage in the fetus are described.

This publication is recommended to both clinicians and basic scientists who are interested in the developing nervous system, its vulnerability to inflammation and the short- and long-term consequences for neurologic development.

The ETHICS & ECONOMICS of Our Current Knowledge Games in Health Care & Mental Health

2/14/2023

Mental Health Care and Health Care in general in the US are already ECONOMICALLY UNSUSTAINABLE --

Further, I would say a BIG DRIVER of our Health Care and Mental Health Crisis are people who are coming with DEVELOPMENTAL SYSTEMIC INFLAMMATION and
- are more VULNERABLE to CHRONIC DISEASE and MENTAL HEALTH ISSUES

Further, it does seem like the SHORT TERM FUTURE is NEURO-DIVERSE ---
- When I say that I am really referring to people with more Developmental Inflammation that we are considering ATYPICAL ---
  - May be more common than we think
  - Coming in more VARIETIES than we think
  - & Appears to be increasing.

Despite that, I think we are in a MUCH BETTER POSITION to understand ROOT CAUSES
- even if we don't completely understand them.
- and even if we need "SUPER COMPUTERS" that we have built and are building to understand our own COMPLEXITY.

"Personal Responsibility" -- ArtStation

Ironically, our PERSONAL RESPONSIBILITY WARRIORS are a big part of the problem --- this is really ramped up in:

EDUCATION
MEDICINE
RELIGION, and
LAW
- which I would humbly submit all often attract NEURO-DIVERSE people

A lot of our PERSONAL RESPONSIBILITY focus has been on:

EXECUTIVE FUNCTIONING, and
- planning
- short term memory
- decision-making
- emotional regulation
METABOLIC ISSUES
- obesity being top of the list
- but fatigue and/or atypical fluctuating energy supplies a big stealth issue

These ISSUES have turned out to be much more individually and idiosyncratically driven than we've typically appreciated.

The KNOWLEDGE we need is not in its RAWEST FORM --- a lot of it is on PubMed (not all of it)

BUT the TASK of SYNTHESIZING all this information is HUGE.

IN THE INTERIM --- we can't keep pretending we know everything --- even if we know a lot.

Val's Take: We're not going to get to a CULTURE OF LIFE without LOVE --- I think that is something Pope John Paul II understood --- I don't think it is something we understand in many of our debates.

Translational Medicine Friday

We're riffing off NPR's Science Friday to create Translational Medicine Friday.

We'll be collecting Research Article recommendations for Clinicians with regard to Cognitive Disability.

There is much in the RESEARCH JOURNALS and we'll just be SKIMMING THE SURFACE.

The POINT is to INCREASE FUNDING for TRANSLATIONAL RESEARCH at the Federal Level for the National Institutes of Health, the Centers for Disease Control, the Nation's Research & Teaching Hospitals and possible collaborations with Medicare and Medicaid providers.

Translational Medicine Friday

Developmental inflammation

The ETHICS & ECONOMICS of Our Current Knowledge Games in Health Care & Mental Health

Translational Medicine Friday

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