Researchers are targeting Pro-Inflammatory Microglia ---including wholesale replacement

Val's Take/Conjecture

• One of the many challenging issues with regard to Neuro-Developmental and Psychiatric Disorders:
  • Such disorders are often the result of Maternal Immune Activation in utero --- affecting:
    • The Central Nervous System
    • The Immune System
    • The Endocrine System, and
    • The Microbiome
    • in highly individual and idiosyncratic ways
• Recognizing the importance of the Immune System and other systems in the body in Neuro-Developmental and Psychiatric Disorders both heightens the seriousness of these disorders, while also playing a role in "DE-PERSONALIZING ILLNESS."
  

Engineering an inhibitor-resistant human CSF1R variant for microglia replacement. (2023)
 
"To mitigate the risks of HSCT and expand the potential for microglia replacement, we engineered an inhibitor-resistant CSF1R that enables robust microglia replacement. ...In sum, we engineered a human CSF1R variant that enables nontoxic, cell type, and …"

Efficient Strategies for Microglia Replacement in the Central Nervous System (2020).

Microglia replacement by nonself cells has been proposed to treat microglia-associated disorders. ...In this study, we develop three efficient strategies for microglia replacement: microglia replacement by bone marrow transplantati …

Treatment of a genetic brain disease by CNS-wide microglia replacement. (2022)

"Here, we developed and characterized a near-complete and homogeneous replacement of microglia with bone marrow cells in mice without the need for genetic manipulation of donor or host. ...This proof-of-concept study suggests that efficient microglia replac …"

Microglia: Agents of the CNS [Central Nervous System] Pro-Inflammatory Response. (2020)
 
"The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. ...Finally, we also discuss current thoughts on the impact of pro-inflammatory microglia in neurodege …"

Targeting microglia-oligodendrocyte crosstalk in neurodegenerative and psychiatric disorders. (2022)
 
"Therefore, an important challenge to studying complex brain diseases is to interrogate relevant interactions between cell types. The microglia-oligodendroglia interaction is an important example that has fundamental roles in physiological state and brain pathologies. Here, …"

Allogenic microglia replacement: A novel therapeutic strategy for neurological disorders. (2023)

Microglia replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy microglia. In this paper, we systematically review the history, rationale and therapeutic perspecti …

Noteworthy perspectives on microglia in neuropsychiatric disorders. (2023)

"Microglia have a profound impact on neuronal survival, brain wiring and synaptic plasticity. ...In this review, we summarized the latest discoveries regarding microglial ontogeny, cell subtypes or state spectrum, biological functions and mechanistic underpinnings of emotional and behavioral disorders."